Introduction:
The online combination of chromatographic mass spectrometry combines the separation capabilities of the chromatograph with the qualitative capabilities of the mass spectrometer for more accurate quantitative and qualitative analysis of complex mixtures. It also simplifies the pre-treatment of the sample and makes sample analysis easier.
Chromatography-mass spectrometry consisting of gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) LC/MS and GC/MS complement each other to analyze compounds of different properties.
The difference between liquid chromatography and mass spectrometry:
GC-MS is the earliest commercial instrument for the analysis of small molecules, volatile, thermally stable, gasification compounds; spectra obtained by electron bombardment (EI) can be compared with standards Library comparison.
LC-MS can solve the following problems: non-volatile compound analysis and determination; analysis and determination of polar compounds; analysis of thermally labile compounds; large molecular weight compounds (including protein, peptide, and more) Analytical determination of polymers, etc.; no commercial library can be compared to the query, you can only build your own library or analyze the spectrum yourself.
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