A recent study by Chinese scholars has shown that glucose metabolism is an independent factor affecting the prognosis of patients with acute myeloid leukemia (AML). The survival time of patients with active glucose metabolism is significantly shortened. Related research papers were published online in the internationally authoritative academic journal Blood.
The research was completed by researchers from the Institute of Systems Biomedicine of Shanghai Jiaotong University, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, and the Institute of Health Sciences of the Shanghai Institute of Life Sciences of the Chinese Academy of Sciences. Experts commented that inhibiting the glycolytic pathway in glucose metabolism can effectively inhibit the malignant proliferation of leukemia cells and significantly enhance the sensitivity of leukemia cells to chemotherapy drugs. Therefore, the glycolysis pathway is expected to become a new target for AML treatment.
According to reports, AML is a very dangerous and highly lethal hematological malignancy, the most common type of leukemia in adults. The main treatment for this type of disease is chemotherapy. After standardized treatment, the 5-year survival rate of patients is only 30% to 40%.
Under the leadership of Prof. Jia Wei and Academician Chen Saijuan, the researchers used a gas chromatography/time-of-flight mass spectrometry platform to analyze serum metabolites in selected AML patients and healthy controls. The researchers first analyzed data from 229 AML patients and 260 healthy controls from Shanghai Ruijin Hospital and found that AML patients had significantly different metabolic profiles. Pathway analysis showed significant signs of glucose metabolism; significant changes occurred in the application of glucose metabolism. The disordered six metabolites constitute a discriminant equation with the value of predicting the prognosis of patients.
Subsequently, the researchers selected 171 AML patients and 186 healthy controls at six blood disease medical centers in Hangzhou, Suzhou, Shenyang, Nanjing, Dalian, and Beijing to verify the results. A high-risk patient with AML identified by the metabolite discriminant equation, an important hallmark of glycolysis and cancer cells is the disorder of glucose metabolism, which is mainly manifested by enhanced glycolysis and inhibition of the tricarboxylic acid cycle (TCA). The TCA cycle was enhanced and the gene expression profile data confirmed this feature.
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