Blow-Irrigation-Sealing Three-in-One (BFS) Sterile System

What is BFS technology?

definition

The BLOW/FILL/SEAL technology applied to the pharmaceutical industry is a kind of aseptic packaging technology. The machine completes the whole blow molding of the plastic containers in a single process under aseptic conditions. Filling and sealing process.

This technology enables the three operations of bottle making, filling and sealing to be completed at the same station in the aseptic condition. The interior of the plastic bottle is not affected by the air in the operating room. The advantages of this technology include: no need to wash the bottle, save water and energy; the equipment covers an area of ​​small, save some of the investment in the power; the use of PP / PE material, plastic bottle production costs are low; finished product is of high quality, and stable and reliable.

System composition

1、Hydraulic system: Mainly used for the drive of equipment operation, such as the transfer of the main mold mechanism from the extrusion position to the filling position, the closing and opening of the main mold and the head forming mold, the lifting and lowering of the tail pulling waste device, etc. movement;
2. Pneumatic system (subsystem can be divided into subsystems): a. General air system: It is mainly used for the operation of cylinders and valves; b. Clean air system: The air adopts sterile filtration, mainly used to support the air of the preforms, Bottle forming air, liquid filling system (time pressure quantification);
3, vacuum system: for the bottle body molding and filling the remaining drops of the pipeline;
4. Mandrel lift control system: Linear motor control is adopted to avoid the risk of hydraulic leakage due to hydraulic components;
5. Thickness control system: thickness control of 300 extrusions;
6, mold agencies;
7, plastic preform extrusion system;
8, liquid filling quantitative system: the use of sterile liquid filtration;
9, online sterilization SIP and online cleaning CIP system;
10. Control system.

Scope of application

(1) Bottles or bags of intravenous injections, rinses, disinfectants, respiratory products, lens care products, etc. (capacity may be 30ml to 1000ml).

(2) Drops for eyes, ears, and nose, small-volume non-intestinal absorption drugs, oral liquids, ointments, ointments, inhalation doses, and drops (volumes may be 0.1 ml to 30 ml).

World famous BFS supplier

The three most famous suppliers of the “Blow-fill-seal” three-in-one aseptic system are among the world's most famous. All three companies have established offices or designated agents in the country:

International BFS New Technologies

Add a layer of aluminum foil packaging

Regardless of high concentration or low concentration of polyethylene, polypropylene, if there is gas or water vapor entering or surrounding it, it will cause changes in its PH value, reduce the product quality, and easy to be melted by the outer carton ink and glue Pollution. To solve this problem, many companies have added a layer of aluminum foil packaging to their products.

Advanced Vision Research also introduced their new product: An eye drop packaged with low-density polyethylene BFS is sealed in a layer of aluminum foil to ensure the quality of the product.

Use inert gas to improve air

WEILER offers another method of packaging air that can improve the stability of pharmaceutical ingredients. In the packaging process, an inert gas, nitrogen, is used to effectively block oxygen. This ensures the stability of the drug.

Nitrogen can be used in packaging and filling

Romgege also produces a machine that can use nitrogen in packaging and filling. This machine-specific BFS process enables the product to be completely performed under non-oxygen conditions in the packaging and filling process, effectively reducing the harm of oxygen in the air to the drug.

Multi-layer co-extrusion

Another BFS device newly designed by ROHMLER can achieve the effect of strengthening the extrusion and enhancing the barrier layer. According to Romgege, using this process, you can perform multiple extrusions on one machine and produce up to five plastic bottles. vITAL Pharmaceuticals offers extruded materials that are not traditional translucent resins, but block the more characteristic polyethylene terephthalate (PFT).