The Annals of Surgery, published in January 2013, published the results of a study by Dr. Hyeong-Gon Moon and others at the Seoul National University Hospital in South Korea. The study targeted MRI after neoadjuvant therapy Whether the accuracy of imaging (MRI) was affected by the molecular characteristics of primary breast cancer and drugs affected by human epidermal growth factor receptor 2 (HER2) as the target.
A more in-depth understanding of the factors that affect the accuracy of breast cancer MRI after neoadjuvant therapy will help MRI to be more suitable for determining the scope of surgery after neoadjuvant therapy.
The study analyzed the imaging and clinicopathological data of 463 patients who had received neoadjuvant therapy. The purpose of this study was to investigate whether molecular subtypes and the application of targeted therapy are related to changes in the accuracy of MRI in predicting the degree of tumor survival.
The researchers found that MRI has the highest accuracy in predicting the survival of triple-negative breast cancer tumors, and the worst accuracy in predicting luminal A subtype tumors (Pearson correlation coefficients are 0.754 and 0.531, respectively). Multivariate analysis shows that estrogen receptor (ER) status is an independent factor that affects the accuracy of MRI. For tumors where HER2 expression increases, the application of HER2 targeted drugs is related to the reduced accuracy of MRI prediction.
The researchers believe that MRI is the least accurate in predicting the degree of tumor survival after neoadjuvant therapy and positive ER. For HER2-positive tumors, the application of HER2 targeted drugs can reduce the accuracy of MRI after neoadjuvant therapy. Therefore, the researchers suggest that after neoadjuvant chemotherapy is performed on patients, these factors should be considered when determining the scope of breastfeeding.
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